Dear Mar12186,
Here's a discussion of Mac donor databases from 2004. GiftMaker Pro and MacTRAK are no longer being sold. DonorPerfect Online is still being sold but I'm not sure about the others that I listed back then. In addition, NorthStar DB (created by one of the developers of the now-defunct eBase) and Easy-Ware work with Macs. And there are web-based systems like DonorPro, Z2 Neon, SalesForce, CommonGround and eTapestry that work with Macs. I assume that Blackbaud's new Now database does as well, but I can't find that info on their web site.
Many of these systems are described in detail in Idealware's Consumers Guide to Low Cost Donor Management Systems.
I know that TechSoup offers Blackbaud Now and eTapestry, I don't see the others listed at the moment.
Robert