I want to make sure that we're understanding what software you're talking about. When I read "ODB," I think of
The Organizer's Database, which is an open source package that runs on Windows, not over the Web. It seems a likely bet, based on your organization's size.
I haven't spent a lot of time in ODB, but what I have looked at left me impressed. I'd strongly encourage you and your organization to ensure that the program doesn't do what you want it to do before you move on. I'd especially strongly encourage you to consider
buying some training or support from Organizers Collaborative, the builders of ODB, before making the decision to move to a different product. There are also lots of good resources on the
Community section of their website.Training and support can make a HUGE difference in how effectively your organization's staff and/or volunteers are able to use the software. When you look at the cost of acquiring software, migrating your data, and
still needing to train staff, that's going to be a much more expensive and time-consuming process than getting the s/w you use now to work for you better.
Especially because you say that ODB is not "intuitive" enough, I think that training is the right place to start, because ODB is, by design, very simple without a lot of features to get in your way. Pretty much any other donor management software is going to be more complex than ODB, and so if the problem isn't lack of features but confusion on how to use the features that are there, switching is unlikely to fix the problem.
If you do decide to move, then the first place to start looking for options is the articles in
Idealware's Constituent Databases section. Idealware exists to review and write about software for nonprofits, and shares much of their content here on TechSoup as well.